CBD Science

New Scientific Discoveries in CBD’s Ability to Reduce Pain and Inflammation

New Scientific Discoveries in CBD’s Ability to Reduce Pain and Inflammation

The interest in CBD, or cannabidiol, has surged since its federal legalization in 2018. By the end of 2024, an estimated 35% of Americans are expected to have tried CBD products. This burgeoning interest is mirrored in the projected market growth, with annualized sales anticipated to reach $20 billion by 2025.


In This Article

CBD’s Potential Role in Pain Management
CBD Clinical Evidence and Bioavailability
  • The Advancements Behind Improved CBD Absorption and Efficacy
CBD Usage Across the United States
The Future of CBD and NextEvo’s Commitment to Future Innovation
  • Resources

With 64% of CBD usage related to pain and inflammation relief, and 49% for stress management, which can potentially improve some forms of inflammation, the demand for effective CBD formulations is higher than ever. 

Today, we will delve into the new scientific discoveries in CBD’s ability to reduce pain and inflammation, exploring how recent research and development efforts are shaping the future of CBD as a cornerstone in natural wellness solutions.


CBD’s Potential Role in Pain Management

CBD, known for its non-psychoactive properties, contrasts with THC (Tetrahydrocannabinol), the compound also known as marijuana, which induces the “high” feeling. This distinction is crucial in understanding CBD's therapeutic potential, especially in the realm of pain management.

CBD interacts with the body's endocannabinoid system, playing a crucial role in regulating functions like sleep, immune responses, and notably, inflammation and pain. Unlike THC, which binds directly to the cannabinoid receptors (CB1 and CB2) in the ECS, CBD indirectly influences these receptors and other non-cannabinoid receptors, contributing to its potential to alleviate pain without psychoactive effects.



Recent scientific studies have begun to unravel how CBD exerts its effects on pain and inflammation. The compound's interaction with G protein-coupled receptors, such as GPR55, and its action on serotonergic receptors (involved in pain perception and mood regulation), showcase a multifaceted approach to pain management.

This interaction suggests that CBD may modify the pain signaling pathways, potentially offering relief in conditions characterized by chronic pain and inflammation. Moreover, CBD’s influence extends to the modulation of inflammatory processes, with research indicating its ability to affect the production of cytokines and other inflammatory molecules, thus addressing pain at its inflammatory roots.



CBD Clinical Evidence and Bioavailability

The exploration of CBD's clinical evidence and its bioavailability is paramount in substantiating its role in pain management. Clinical trials, such as the ORAVEXX study, have illuminated CBD's potential to manage pain effectively, particularly in post-operative scenarios.

Patients in these studies reported substantial pain relief when using CBD in conjunction with conventional pain medications like Percocet, highlighting CBD's ability to enhance pain management regimens without the adverse effects typically associated with cannabis-based products.

These findings are critical in positioning CBD as a viable option for pain relief in medical practice, particularly for patients seeking alternatives to traditional painkillers that may carry risks of dependency or significant side effects.




The bioavailability of CBD, or the proportion of the compound that enters the circulation when introduced into the body, is a crucial factor in its therapeutic effectiveness. Oil-based CBD formulations, commonly used in the market, are notorious for their low bioavailability, which can be as little as 6% to 10%.

This low absorption rate significantly hampers the potential benefits of CBD, necessitating higher doses that may not always result in proportional increases in efficacy. In contrast, water-soluble CBD formulations have emerged as a superior alternative, offering enhanced absorption rates and ensuring a more effective delivery of CBD's therapeutic effects. 

This increased bioavailability not only optimizes the efficacy of CBD in pain and inflammation management but also reduces the likelihood of gastrointestinal side effects, often associated with oil-based formulations.


The Advancements Behind Improved CBD Absorption and Efficacy

Advancements in CBD emulsion technologies, including nanoemulsions and microemulsions, have furtherimproved the bioavailability of CBD, allowing for more efficient lymphatic absorption and reducing the impact on liver metabolism.



This development is critical in maximizing the potential of CBD to alleviate pain and inflammation. As research progresses, the focus on improving CBD bioavailability continues to grow, with studies indicating that taking CBD with food can triple its absorption rate, enhancing its therapeutic impact. 

Thus, understanding and improving the bioavailability of CBD is integral to harnessing its full potential in pain and inflammation management, leading to more effective and patient-centered therapeutic outcomes.


CBD Usage Across the United States

While consumer education around the potential therapeutic benefits of CBD is in it’s early stages, it’s clear, that the message is starting to resonate around the United States.

California stands out as a significant hub for CBD consumption, with a prominent demographic of 35-44-year-olds, especially women, leading the charge in embracing CBD products. This trend highlights the shift towards natural wellness solutions and the growing trust in CBD's therapeutic properties.

Nationally, the legal landscape for CBD reflects its acceptance, with 47 out of 50 states legalizing its use in various forms. Despite the prevalence of oil-based CBD products, there's a noticeable shift towards more bioavailable forms like CBD gummies, which are on track to become a major market segment.

Projected to reach a market cap of $19.4 billion by 2030, CBD gummies signify the evolving consumer preference for effective and convenient CBD solutions. This trend aligns with the broader acceptance and integration of CBD into daily wellness routines, underscoring its potential as a mainstream natural remedy for pain associated with inflammation.


The Future of CBD and NextEvo’s Commitment to Future Innovation

As we delve deeper into the world of CBD, it's clear that its trajectory is one of innovation and expanding influence.

The rising adoption rates, particularly among younger demographics, underscore a societal shift towards natural and effective remedies for health and wellness challenges, particularly in pain and inflammation management.

The ongoing advancements in CBD research, focusing on enhancing bioavailability and efficacy, are paving the way for more sophisticated and potent formulations.

NextEvo Naturals stands at the forefront of this evolution, committed to driving the future of CBD through scientific rigor and innovative product development. Our dedication to creating high-quality, water-soluble CBD products, powered by our proprietary SmartSorb™ technology, exemplifies our commitment to delivering superior bioavailability and therapeutic benefits.

As we continue to explore and harness the full potential of CBD, NextEvo Naturals remains steadfast in its mission to provide products that not only meet but exceed the expectations of our consumers, ensuring a future where CBD is a cornerstone of natural wellness and effective pain management.



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